Modeling and Simulation of Signal Transduction Pathways

Mark Moeller

Biochemistry University of Bielefeld, Germany

2002. 9. 16

Our group is concerned in four-dimensional modeling of intracellualr signaling. The complexity of such processes makes in silico approaches necessary for an understanding.
I gave an overview on signal transduction in general and closer look on the phosphoinositol-pathway.
Mathematical modeling demands for good results the existence of reliable data, e.g. concentrations or rate constants. Therefore I described important steps for a modeling approach.
I explained differences between the deterministic and stochastic approach on modeling chemical reactions and finally outlined the aims of our project to establish a simulator for modeling a human hepatocyte including database information and data provided by confocal microscopy. 


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Last update: Oct. 11, 2002