We can solve problems of biology using micro- and
2004. 5. 17
The lithography techniques of the semiconductor
industry can be used to attack problems of biological interest. For example, we have constructed nanochannels
(100 nm width)" on quartz wafers to mimic pores found in gel and have imaged
mega-base long DNA molecules moving through a nanochannel array chip. We are pursuing this technology to eventually
sequence genomic DNA. We have also constructed maze and square (250 µm X 250 µm)
chips with an opening (10~30 µm) to figure out the influence of the topology on
bacterial social behaviors. It has been observed on these chips that
starting from a homogeneously distributed suspension of bacteria in a complex
environment, the cells self-aggregate in confined geometries. Our results show
that bacteria search out each other in a collective manner and that the
mathematics of the process confines them to highly enclosed spaces (reference 1,2).
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