We can solve problems of biology using micro- and nanodevices?

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2004. 5. 17

 
The lithography techniques of the semiconductor industry can be used to attack problems of biological interest.  For example, we have constructed nanochannels (100 nm width)" on quartz wafers to mimic pores found in gel and have imaged mega-base long DNA molecules moving through a nanochannel array chip.  We are pursuing this technology to eventually sequence genomic DNA. We have also constructed maze and square (250 µm X 250 µm) chips with an opening (10~30 µm) to figure out the influence of the topology on bacterial social behaviors. It has been observed on these chips that starting from a homogeneously distributed suspension of bacteria in a complex environment, the cells self-aggregate in confined geometries. Our results show that bacteria search out each other in a collective manner and that the mathematics of the process confines them to highly enclosed spaces (reference 1,2).

 

This page is maintained by Wha-Jin Lee (wjlee@bi.snu.ac.kr).
Last update: May, 5, 2004