Signaling Mechanisms for Growth, Development, and Toxin Production in Filamentous Fungi
University of Wisconsin-Madison
2006. 2. 22
301-421, 11:00-12:00 AM
Fungi and their toxic secondary metabolites (mycotoxins) have tremendous impact on human health, agriculture, and socio-economy. Mycotoxin contamination of foods and feeds poses serious health hazards to animals and humans. Given the importance of a number of fungi as causal agents of human, animal and/or plant disease and problems caused by mycotoxins, new approaches to control the problems must be identified. We found that two antagonistic signaling pathways control vegetative growth, sporulation and mycotoxin production in the model eukaryote Aspergillus nidulans. We have been investigating: 1) functions of the components of heterotrimeric G protein signaling that regulate vegetative growth and sexual spore formation, and 2) the mechanisms underlying the initiation of spore formation, toxin production and maintenance of intact fungal spores. Progress made on understanding the signaling mechanisms controlling growth, development and secondary metabolism in A. nidulans will be presented.
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