Mapping the retinal connectome with EyeWire,

an online community for "citizen neuroscience

November 6,  2012, 2012 11:00 AM

302- 308



According to a doctrine known as connectionism, brain function and dysfunction depend heavily on patterns of connectivity between neurons. Connectionism has been explored theoretically with mathematical models of neural networks since the 1940s. It has proved difficult to test these models through activity measurements alone. For conclusive empirical tests, information about neural connectivity is also necessary, and could be provided by new imaging methods based on serial electron microscopy. The bottleneck in using these new methods is now shifting to the data analysis problem of extracting neural connectivity from the images.  Our capacity to acquire "big data" from the brain has far outpaced our ability to analyze it.  My lab has been developing computational technologies to deal with this data deluge.  Based on these innovations, we have launched EyeWire, an online community that mobilizes the public to map the retinal connectome by playing a coloring game.  Players analyze nanoscale images by interacting with one another and with artificial intelligence based on machine learning. I will describe preliminary efforts to map the connections of the J type of ganglion cell and understand the mechanisms of its direction selectivity.

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Last update: November 8, 2012